Summary of changes in Revised Venous Clinical Severity Score (rVCSS) components. Assessments of mean ± SD symptom severity scores (0 = none, 1 = mild, 2 = moderate, 3 = severe) for each rVCSS component indicate significant improvements in pain, venous edema, skin pigmentation, inflammation, and induration at 1 year. The use of compression therapy significantly increased from baseline to 1-year visit. n = 433-442 at baseline and n = 283-285 at 1-year visit. ∗P < .0001; P values are derived from the Wilcoxon signed-rank test with comparison against baseline values.