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. 2023 Dec 4;2(6Part B):101206. doi: 10.1016/j.jscai.2023.101206

Figure 1.

Figure 1

Schema outlining the 4 mainstay guideline-directed medical therapies in the treatment of chronic heart failure with reduced ejection fraction (HFrEF) and additional treatment options for patients with persistent symptoms. ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor/neprilysin inhibitor; BB, β-blocker; GDMT, guideline-directed medical therapy; HR, heart rate; MRA, mineralocorticoid receptor antagonist; NSR, normal sinus rhythm; NYHA, New York Heart Association; RAAS, renin-angiotensin-aldosterone system; SGLT2i, sodium-glucose cotransporter-2 inhibitor.