Table 3.
Mitochondrial depolarization (JC-1) levels in flow cytometry of IC50 concentrations of Cl-amidine and carmustine in U-87 MG cells (control: 0.1% DMSO, n = 3, mean ± standard deviation).
| Groups | Viable cells % (upper quadrant) | JC-1-positive cells % (lower quadrant) |
|---|---|---|
| Control | 87.7 ± 2.0 | 12.3 ± 2.0 |
| Cl-amidine | 45.3 ± 11.51 | 54.7 ± 11.60 |
| Carmustine | 41.4 ± 3.80 | 58.6 ± 3.80 |
Cl-amidine = chlorine-amidine, DMSO = dimethyl sulfoxide, IC50 = half maximal inhibitory concentration, JC-1 = 5,5', 6,6'-tetrachloro-1,1', 3,3' tetraethyl benzimidazolyl carbocyanine iodide, U-87 MG = human glioblastoma cells.