Table 2.

Two-sample Mendelian randomization estimations showing the effects of diet-derived antioxidants on the risk of small cell lung cancer.

Exposures	Inverse variance weighted		Weighted median		MR Egger
	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
Carotene	0.73 (0.55–0.95)	.02	0.74 (0.51–1.06)	.10	0.58 (0.13–2.63)	.51
Retinol	0.16 (0.01–2.18)	.17	0.22 (6.6E–03–7.29)	.40	0.01 (2.2E–05–5.61)	.21
Selenium	3.6E–22 (9.2E–45–14.9)	.06	3.2E–28 (2.6E–57–39.2)	.06	9.9E+20 (2.9E–56–3.4E+97)	.61
Vitamin C	1.2E+05 (0.28–5.4E+10)	.08	1.2E+03 (1.1E–05–1.4E+11)	.45	2.3E–03 (1.6E–14–3.4E+08)	.65
Vitamin E	2.5E+05 (4.7E–12–1.3E+32)	.53	0.33 (1.3E-20–8.5E+22)	.89	2.5E + 03 (2.7E–52–2.3E+58)	.91
Zinc	1.1E–06 (1.9E–19–5.7E+06)	.36	4.8E–04 (2.6E–19–9.1E+11)	.67	2.7E+05 (1.3E–31–5.9E+41)	.78
Exposures	Simple mode		Weighted mode		MR-PRESSO
	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
Carotene	0.76 (0.49–1.16)	.24	0.76 (0.50–1.14)	.21	0.72 (0.63–0.83)	<.01
Retinol	2.45 (8.9E–03–668.09)	.76	0.03 (3.3E–04–2.76)	.17	0.16 (0.02–1.15)	.15
Selenium	9.6E–19 (2.5E–62–2.8E+20)	.45	1.8E–20 (1.2E–60–2.8E+20)	.37	1.3E–24 (2.8E–42–6.4E–07)	.03
Vitamin C	4.6E+05 (4.1E–08–5.1E+18)	.41	4.4E+02(2.7E–08–7.3E+12)	.62	1.2E+5(0.75–2.0E+10)	.07
Vitamin E	0.01 (7.8E–37–1.3E+32)	.91	0.05 (2.7E–32–1.1E+29)	.94	2.5E+05 (4.7E–12–1.3E+22)	.54
Zinc	6.2E-05 (1.4E–32–2.7E+23)	.77	2.1E–03 (1.2E–30–3.5E+24)	.85	1.1E–06 (2.0E–19–5.7E+07)	.37