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. 2024 May 27;115(8):2673–2685. doi: 10.1111/cas.16204

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© 2024 The Author(s). Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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HK2 is highly expressed in PDAC and correlated with poor prognosis of patients with PDAC. (A) Expression of HK2 in 60 samples of human PDAC tissues and matched adjacent normal tissues by immunohistochemical (IHC) staining with an anti‐HK2 antibody. Representative images are shown. Scale bars, 20 μm. (B) Comparative analysis of HK2 expression between PDAC tissues and matched adjacent normal tissues. ***p < 0.001. (C) Correlations between HK2 expression levels and PDAC clinicopathological parameters. (D) Kaplan–Meier plots and p‐values of the log‐rank test for comparing survivals of PDAC patients with high (staining score, 5–12) and low (staining score, 0–4) expression of HK2. (E) Lysates of the indicated cells were prepared. Immunoblot analyses were performed with the indicated antibodies.