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Diagram displaying the regulation of NF‐κB signaling by the nonmetabolic function of HK2. HK2‐mediated phosphorylation of IκBα at T291 in PDAC cells, leading to IκBα degradation and subsequent activation of NF‐κB for the upregulation of downstream target transcription. HK2 nonmetabolic activity‐promoted activation of NF‐κB stimulates the proliferation, migration, and invasion of PDAC cells.
