TABLE 3.
Potential drug targets in Escherichia coli that confer antibiotic resistance.
| S/No | Antimicrobial resistance mechanism | Genes/proteins |
|---|---|---|
| 1 | Antibiotic activation enzyme | KatG |
| 2 | Antibiotic resistance gene cluster, cassette, or operon | MarA, MarB, MarR |
| 3 | Antibiotic target in susceptible species | Alr, Ddl, dxr, EF-G, EF-Tu, folA, Dfr, folP, gyrA, gyrB, inhA, fabI, Iso-tRNA, MurA, rho, rpoB, rpoC, S10p, S12p |
| 4 | Antibiotic target protection protein | BcrC |
| 5 | Efflux pump conferring antibiotic resistance | AcrAB-TolC, AcrZ, EmrAB-TolC, MacA, MacB, MdfA/Cmr, MdtEF-TolC, MdtL, TolC/OpmH |
| 6 | Gene conferring resistance via absence | gidB |
| 7 | Protein altering cell wall charge conferring antibiotic resistance | PgsA |
| 8 | Regulator modulating expression of antibiotic resistance genes | AcrAB-TolC, EmrAB-TolC, GadE, H-NS, OxyR |