TABLE 1.

CBL is associated with pathways in different cancers.

Classify	Types	Cell model	Signaling pathway	References
Glioma	c-CBL CBL-b	U-87MG, LN229, T98G U251, A172 SHG-44, SU2	EGFR redox/Fyn/c-Cbl SETA/CIN85/Ruk	Zhang et al. (2013a) Stevens et al. (2014) Schmidt et al. (2003)
Lung cancer	c-CBL CBL-b CBL-c	PC9, H1975, H358 A549, H1299 SPC-A1, SCC-35 SW900, HCC827	EGFR, MET β-catenin ERK1/2-GSK3β PI3K-Akt c-Src/AKT	Eggermont et al. (2023) Jang et al. (2011) Li et al. (2018a) Zhong et al. (2015) Lee et al. (2018)
Liver cancer	c-CBL	SMMC-7721, MHCC97H Huh-7, Hep3B	AP-1/NF-AT1	Zhang et al. (2015a) Jiang et al. (2017)
Pancreatic cancer	c-CBL CBL-b CBL-c	HEK293T, PaCa-2 SW1990 Patu8988, Bxpc-3 Aspc-1 Jr305, panc-1, panc-28 Capan-1/2	PI3K/AKT Erk EGFR c-Met/Crk/JNK NF-κB Met	Donahue et al. (2012) Song et al. (2020) Jang et al. (2020) Chekmarev et al. (2021) Wesley et al. (2018) Hill et al. (2010)
Gastric cancer	c-CBL CBL-b CBL-c	MKN45, MKN74 HGC-27 MGC803 SGC-7901 AGS SNU-1	EGFR PI3K/Akt MAPK/ERK miR-940/CBL-b/STAT5a ERK1/2 Met JWA/c-CBL/HER2	Dong et al. (2010) Qu et al. (2009a) Qu et al. (2011) Fan et al. (2018) Qi et al. (2019) Lai et al. (2012) Deng et al. (2020)
Colorectal cancer	c-CBL CBL-b	HCT116, SW480 HT29, Caco-2	EGFR Wnt/β-catenin	Wang et al. (2012) Kumaradevan et al. (2018)
Renal cancer	c-CBL	769-p, A-498 ACHN, CAKI-1 OS-RC-1	Met EGFR Wnt/β-catenin	Maroun and Rowlands (2014) Sahu et al. (2022) Chitalia et al. (2013)
Prostate cancer	c-CBL CBL-b	LNCap, PC3 DU145, C4-2B	EGFR Erk1/2	Kitai et al. (2017) Shrestha et al. (2018)
Thyroid cancer	c-CBL	IHH-4 K1, TPC-1	Wnt/β-catenin circ-ITCH/miR-22-3p/CBL	Guo et al. (2021) Guo et al. (2021)
Melanoma	c-CBL CBL-b	MEL202 MMAc-SF	FAK-GRB2-SRC PD-L1/PD-1	Nihal and Wood (2016) Fujiwara et al. (2017)
Ovarian cancer	c-CBL	SKOV3 A2780	EGFR RAS-MAPK	Hanson et al. (2014) Hanson et al. (2014)
Breast cancer	c-CBL CBL-b CBL-c	MDA-MB-231, mSKBR-3 MCF-12A, MDA-MB-231 HBL101, MDA-MD-435 HS598TMCF-10A MCF-7, BT-20 MCF-10F, AU565 ZR-75-1, BT-483, BT-474	EGFR, RANKL/RANK Src-Akt/ERK PI3K/Akt, MAPK/Erk PI3K-PKB-GSK-3	Flanders et al. (2003) Zhang et al. (2015b) Li et al. (2018c) Chen et al. (2018)