TABLE 2.

Potential therapeutic approaches.

Drug		Types	Signaling pathway	References
Western medicine	DEX	CBL	gsk-3β	Jeon et al. (2020)
	Licochalcone A	c-CBL	Met	Han et al. (2022)
	Dasatinib	CBL	EGFR	Chang et al. (2008)
	Cetuximab	CBL-b	EGFR	Yu et al. (2016)
	5-fluorouracil	CBL-b	EGFR, ERK, Akt	Feng et al. (2013)
	Olaparib	CBL-c	EGFR	Frankum et al. (2015)
	Flavones	c-CBL	Notch	Zhu et al. (2020)
Natural product	Bufalin	CBL-b	Akt/mTOR/p70S6K	Qi et al. (2019)
	β-elemene	c-CBL, CBL-b	Akt	Zhang et al. (2013b)
	Proanthocyanidins	c-CBL	EGFR	Daveri et al. (2021)
	Berberine	c-CBL	β-catenin	Ruan et al. (2017)
	Chloroquine	c-CBL	TRAIL	Park et al. (2016)
	Acety tanshinone IIA	c-CBL	EGFR	Huang et al. (2020)
	Arsenic trioxide	CBL-b	PI3K/Akt	Zhang et al. (2012)