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. 2024 Feb 16;21(8):1492–1500. doi: 10.1038/s41592-024-02191-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — Rows correspond to macrogene numbers, and columns correspond to cluster numbers. Genes composing each macrogene are listed in Supplementary Data Table 3. Cluster 1 expresses collagen genes like Col6a2 (macrogene 1540) which are known fibroblast markers¹⁸. Cluster 2 expresses Nr2f1 (macrogene 197) which was identified as a trabecular meshwork marker¹⁸. Cluster 3 expresses Rspo genes (macrogene 583). Rspo4 was identified as a marker in human JCT¹⁸. Cluster 4 expresses Angptl7 (macrogene 479) which was identified as a JCT marker¹⁸. Cluster 5 expresses corneal endothelium markers including Ca3 (macrogene 1300). Additionally, Cluster 5 contains a macrogene composed of Slc4a genes. Another solute carrier family (SLC) gene^45,46, Slc11a2 was identified as differentially expressed in human corneal endothelium¹⁸.