Table 4.

Trends in serum biomarker levels in patients receiving total intravenous anesthesia vs. patients receiving inhalation anesthesia.

Laboratory parameters	IA1	TIVA1	IA		TIVA
			Trend from baseline to 1 h.2	Trend from baseline to 24 h.2	Trend from baseline to 1 h.2	Trend from baseline to 24 h.2
Absolute NLR	<0.001	<0.001	↑<0.001	↑<0.001	↑<0.001	↑<0.001
Relative NLR	<0.001	<0.001	↑<0.001	↑<0.001	↑<0.001	↑<0.001
CRP, mg/l	<0.001	<0.001	0.248	↑<0.001	0.999	↑<0.001
IgA, g/l	0.006	0.002	0.109	↑0.006	0.401	0.154
IgM, g/l	0.015	0.094	0.065	↓0.028	NA	NA
IgG, g/l	<0.001	0.001	↓0.049	↓<0.001	0.999	↓0.010
C3, g/l	0.001	0.083	↓0.001	0.074	NA	NA
C4, g/l	0.014	0.103	↓0.013	0.459	NA	NA
MMP-9, ng/ml	NA	NA	NA	0.1633	NA	0.3743
Absolute neutrophil count, 109/L	<0.001	<0.001	↑<0.001	↑<0.001	↑<0.001	↑<0.001
Absolute lymphocyte count, 109/L	<0.001	<0.001	↓<0.001	↓<0.001	↓<0.001	↓<0.001
Relative neutrophil count, %	<0.001	<0.001	↑<0.001	↑<0.001	↑<0.001	↑<0.001
Relative lymphocyte count, %	<0.001	<0.001	↓<0.001	↓<0.001	↓<0.001	↓<0.001
Т cells (СD3+), %	0.001	<0.001	↓0.07	0.540	↓0.028	0.485
T helper cell (CD3+CD4+), %	0.020	0.005	0.999	0.07	0.121	0.750
Cytotoxic T cell (CD3+CD8+), %	0.016	0.004	0.999	↓0.016	0.297	0.297
Immunoregulatory index (CD4+/CD8+ ratio)	0.034	0.003	0.999	↑0.037	0.258	0.258
В cells, %	<0.001	<0.001	↑<0.001	↑<0.001	↑0.010	↑<0.001
NK cells, %	0.001	<0.001	0.999	↓0.016	0.662	↓0.018
Т cells (СD3+), В cells (СD19+CD3), NK cells (CD3-CD16+), %	0.805	0.905	NA	NA	NA	NA

¹Friedman test, ²Dunn’s post-hoc test; ³Wilcoxon signed-rank test; NA, not applicable; IA, inhalation anesthesia; TIVA, total intravenous anesthesia.

The symbols ↑ and ↓ represent an increase and a decrease in the parameter over time, respectively.