FIGURE 1.

Workflow of AsmMix. AsmMix requires both TGS long reads and SLR co-barcoded reads as input, generates preliminary haplotype-collapsed assemblies using long reads and haplotypes using trio binning and barcode cloud information, merges two sets of genome sequences, and finally reconstructs the haplotype-resolved assemblies. The gray lines indicate sequencing long reads and long fragments data (solid and dashed), the red and blue blocks refer to maternal and paternal allelic sites, the red and blue lines refer to reconstructed maternal and paternal haplotypes, and yellow lines and blocks represent the haplotype-collapsed assembly and regions, respectively.