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. 2024 Aug 9;8:176. doi: 10.1038/s41698-024-00660-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — a UMAP visualization of all re-clustered monocytes/macrophages in the phs002065 dataset. b Heatmaps for monocytes/macrophages clusters in the phs002065 dataset for select pro-inflam and pro-tumor TAMs markers highlighted. c Heatmap shows the difference in pathway activities scored by GSVA per cell between different monocytes/macrophage clusters in the phs002065 dataset. d The expression of co-inhibitory molecules of monocytes/macrophages clusters in the phs002065 dataset. e Volcano plot showing upregulation of markers specific for pro-inflam TAMs in the Cluster5 (ICB responders) in comparison with the Cluster5 (ICB non-responders). R: responders including ICB PR patients; NR: non-responders including ICB SD/PD patients. f GSEA shows enriched pathways in the Cluster5 (ICB responders). R responders including ICB PR patients, NR non-responders including ICB SD/PD patients. g UMAP visualization of all re-clustered monocytes/macrophages in the GSE120575 dataset. h Violin plots depicting AUCell scores for gene signatures derived for pro-inflam and pro-tumor TAMs across all re-clustered monocytes/macrophages in the GSE120575 dataset. i UMAP plots showing the distribution of pro-inflammatory and pro-tumor TAMs in non-responders after immunotherapy (top); fraction of cells belonging to each immunotherapy phase for in Cluster2 and Cluster5; each point represents one sample; R responders including ICB CR/PR patients, NR non-responders including ICB SD/PD patients. Percentage corrected according to the total number of cells per sample; error bars indicate the 95% CI for the calculated relative frequencies; p value using the default Wilcoxon rank sum test (bottom).