Table 2.

In silico docking analysis of binding affinity and pose fitness between novel annulated Benzo[h]chromenes and C. pipiens neural targets (AChE, nAChRs, and VGSC α subunit).

Compd	AChE		nAChRs		VGSC α subunit
	*S	**RMSD Refine	S	RMSD Refine	S	RMSD Refine
1a	− 6.73	1.85	− 5.55	1.61	− 5.99	0.98
1b	− 6.63	1.11	− 5.65	0.83	− 5.30	1.34
3	− 6.86	1.94	− 5.99	1.14	− 6.04	1.69
5a	− 6.64	1.76	− 5.91	1.51	− 5.83	1.90
5b	− 7.15	1.08	− 6.19	1.56	− 5.66	0.85
6	− 8.11	1.31	− 6.27	1.20	− 6.42	1.81
7	− 7.40	1.01	− 6.67	1.35	− 6.18	1.73
8	− 6.61	1.41	− 5.48	1.19	− 5.49	1.32
9	− 7.25	1.32	− 6.44	1.06	− 6.09	1.14
10	− 8.33	1.61	− 6.74	1.34	− 6.28	1.62
11b	− 8.01	1.89	− 7.10	1.52	− 6.74	1.90
12	− 7.90	1.12	− 5.88	1.39	− 6.24	1.55
13	− 7.88	1.66	− 6.04	0.72	− 6.20	1.64
14	− 7.60	1.80	− 6.40	1.72	− 6.74	0.77
16	− 8.28	1.50	− 6.79	1.64	− 6.56	1.00
Reference insecticide	Chlorpyrifos		Nitenpyram		Indoxacarb
	− 6.89	1.27	− 6.04	1.78	− 6.61	1.55

*S: Docking Score, kcal/mol.

**RMSD: Root mean square deviation, Å.