Table 4.
Clinical and biological features of patients during their entire hospital stay
| Variables | Reunion (N = 215) | Mayotte (N = 102) | P-Value* |
|---|---|---|---|
| Clinical Features, n (% of known values) | |||
| Fever | 103 (51) | 59 (67) | 0.011 |
| Muscle Pain | 96 (45) | 34 (42) | 0.610 |
| Arthralgia | 37 (17) | 24 (32) | 0.011 |
| Digestive Tract Symptoms | 153 (74) | 32 (40) | <0.001 |
| Jaundice | 118 (56) | 23 (27) | <0.001 |
| Cough | 20 (9) | 9 (11) | 0.731 |
| Hemoptysis | 30 (14) | 4 (5) | 0.013 |
| Alveolar Hemorrhage† | 18 (9) | 1 (1) | 0.009 |
| Bleedings | 66 (31) | 16 (24) | 0.277 |
| Headache | 36 (17) | 35 (46) | <0.001 |
| Meningitis | 2 (1) | 3 (3) | 0.143 |
| Biological Features, Mean ± SD (number of known values) | |||
| Total Bilirubin Max (µmol/L) | 215 ± 438 (198) | 134 ± 235 (90) | 0.155 |
| AST Max (UI/L) | 345 ± 2179 (209) | 185 ± 366 (77) | 0.522 |
| ALT Max (UI/L) | 147 ± 398 (207) | 124 ± 149 (76) | 0.627 |
| Creatininemia Max (µmol/L) | 347 ± 286 (212) | 267 ± 374 (78) | 0.053 |
| Proteinuria, N‡ (%) | 61/170 (36) | 13/94 (14) | <0.001 |
| Hematuria, N‡ (%) | 107/170 (63) | 48/94 (51) | 0.081 |
| Platelets Min (× 109/L) | 68 ± 65 (212) | 105 ± 71 (90) | <0.001 |
| Hemoglobin Min (g/dL) | 10.5 ± 2.5 (212) | 10.5 ± 2.6 (90) | 0.972 |
| Neutrophils Max (× 109/L) | 12.1 ± 6.5 (199) | 11.2 ± 7.9 (71) | 0.388 |
| Lymphocytes Min (× 109/L) | 0.74 ± 0.93 (199) | 1.03 ± 1.24 (83) | 0.032 |
| PR Min (%) | 77 ± 18 (206) | 71 ± 16 (83) | 0.017 |
| CK Max (UI/L) | 3,809 ± 6,193 (156) | 3,277 ± 11,027 (19) | 0.750 |
| CRP Max (mg/L) | 316 ± 880 (177) | 279 ± 107 (78) | 0.712 |
ALT = alanine-amino transferase; AST = aspartate-amino transferase; CK = creatine kinase; CRP = C-reactive protein; Max = maximal value during hospital stay; Min = minimal value during hospital stay; PR = prothrombin ratio. Proteinuria = positive urinary stick or proteinuria >10 cells/mm3. Hematuria = positive urinary stick or hematuria >10 cells/mm3. Among patients admitted to the hospital, admission to the ICU was higher on Reunion (59%, n = 127) than on Mayotte (18%, n = 18; P <0.001) (Table 5).
Significant differences are bolded.
Alveolar hemorrhage is defined by the association of hemoptysis and radiological interstitial lung disease.
Calculation based on all urine samples collected.