Table 5.

Secondary endpoints analysis among hospitalized patients

Variables	Reunion (N = 215)	Mayotte (N = 102)	P-Value*
Delay Symptoms–Hospitalization in Days, Mean ± SD (n)	4.7 ± 2.4 (202)	4.1 ± 4.7 (83)	<0.001
Delay Symptoms–Antibiotics in Days, Mean ± SD (n)	4.6 ± 2.2 (199)	4.0 ± 4.2 (77)	<0.001
Length of Hospitalization in Days, Mean ± SD (n)	8.8 ± 6.5 (211)	5.8 ± 4.9 (90)	<0.001
Organ Impairment,† N (%)
Kidney	123 (57)	29 (28)	<0.001
Hepatic	103 (48)	20 (20)	<0.001
Respiratory	59 (27)	7 (7)	<0.001
Hemodynamic	69 (32)	20 (20)	0.018
Hematology	35 (16)	9 (9)	0.063
Cardiac	21 (10)	3 (3)	0.020
Neurology	10 (5)	2 (2)	0.350
Total Organ Impairment, Median [IQR]	2 [0–3]	0 [0–2]	<0.001
KDIGO Score ≥2, n (%)	123 (57)	29 (28)	<0.001
ICU Admission, n (%)	127 (59)	18 (18)	<0.001
IGS II Score, Median [IQR]	33 [22–46]	35 [20–58]	0.207
Oxygen Use	66 (31)	12 (12)	<0.001
Mechanical Ventilation, n (%)	23 (11)	5 (5)	0.075
ARDS, n (%)	13 (6)	0	0.012
RRT, n (%)	49 (23)	9 (9)	0.002
Transfusion	36 (17)	12 (12)	0.239
Intravenous Fluid Therapy	75 (35)	41 (40)	0.361
Vasoactive Drug, n (%)	37 (17)	10 (10)	0.074
Fatality, n (%)	4 (1.9)	2 (2.0)	–

ARDS = acute respiratory distress syndrome; ICU = intensive care unit; IGS = simplified gravity index (calculated according to the worst values obtained during the first 24 hours of admission in the ICU); IQR = interquartile range; KDIGO = kidney disease improving global outcomes (scale 0–3); RRT = renal replacement therapy.

^*Significant differences are bolded.

^† Definition of organ impairment: Kidney: KDIGO score ≥2 or the need for renal replacement therapy; Hepatic: total bilirubin ≥100 µmol/L; Respiratory: need for oxygen therapy or mechanical ventilation; Hemodynamic: intravenous fluid therapy, use of vasoactive drug; Hematology: need for labile blood product transfusion; Cardiac: myocarditis, acute heart failure; Neurology: Glasgow score <15 or meningitis.