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. 2024 Jul 31;13(15):1287. doi: 10.3390/cells13151287
GZMB+ B cells: Granzyme B positive B cells with regulatory properties.
Induced GZMB+ B cells: GZMB+ B cells generated according to the in vitro protocol described in Chesneau et al. [19].
Natural GZMB+ B cells: B cells from donor’s blood or biopsies expressing GZMB without any restimulation in vitro.
GZMB B cells: B cells used to determine the characteristics of GZMB+ B cells. For the dataset generated after in vitro induction, GZMB B cells correspond to the conditions that did not receive any stimulation (i.e., total resting B cells after 3 days), as GZMB expression is transient.
TOL: Patients with no immunosuppression for at least one year and with stable creatinine < 150 mmol/L and proteinuria < 1 g/24.
STA: Patients with stable graft function (creatinine < 150 mmol/L and proteinuria < 0.2 g/g creatinine) for at least 3 years under standard immunosuppression (calcineurin inhibitors [CNIs], antimetabolite ± corticosteroids).
ABMR: Patients with histology-proven antibody-mediated rejection.
DEG: Differentially expressed gene.