Table 2.
Main characteristics and results of studies assessing the diagnostic performances of 5-ALA for the identification of anaplastic foci in DLGGs.
| Study | Design | Effectives | Main Conclusions |
|---|---|---|---|
| Widhalm, 2010 [57] | Prospective, monocentric 11C Methionine PET (WHO 2007) |
17 gliomas without significant CE: 8 (47.1%) grade 2 9 (52.9%) grade 3 |
Performance of negative fluorescence for low-grade detection Sensibility = 100%. PPV = 89%. Performance of fluorescence for high-grade detection Sensibility = 89%. PPV = 100%. |
| Floeth, 2010 [60] |
Prospective, multicentric 18F FET PET (WHO 2007) |
38 gliomas with CE in 13 (43.3%) cases: 17 (44.7%) grade 2 19 (50%) grade 3 2 (5.3%) grade 4 |
Performance of negative fluorescence for low-grade detection Sensibility = 94%. Performance of fluorescence for high-grade detection Sensibility = 57%. Hypermetabolism in 18F-FET 7/17 (41%) grade 2 gliomas. 18/21 (86%) grade 3–4 gliomas. |
| Ewelt, 2011 [58] |
Prospective, monocentric 18F FET PET (WHO 2007) |
30 gliomas with CE in 12 (40%) cases: 13 (43.3%) grade 2 15 (50%) grade 3 2 (6.7%) grade 4 |
Performance of negative fluorescence for low-grade detection Sensibility = 92.3%. Performance of fluorescence for high-grade detection Sensitivity = 70.6%. Specificity = 92.3%. Negative fluorescence and positive FET uptake 6/13 (46.2%) grade 2 gliomas. Positive fluorescence and FET uptake 1/13 (7.7%) grade 2 gliomas. |
| Widhalm, 2013 [59] | Prospective, monocentric 18F FET or 11C Methionine PET (WHO 2007) |
59 gliomas without significant CE 33 (55.9%) grade 2 26 (44.1%) grade 3 |
Performance of negative fluorescence for low-grade detection Sensibility = 91%. Performance of fluorescence for high-grade detection Sensitivity = 88%. Specificity = 89%. PPV = 85%. |
| Watts, 2023 [61] |
Prospective, tricentric (WHO 2021) |
89 suspected HGGs, including finally 1 (1.1%) grade 1 8 (9.0%) grade 2 3 (3.4%) grade 3 77 (86.5%) grade 4 |
Performance of negative fluorescence for low-grade detection Sensibility = 87.5%. Performance of fluorescence for high-grade detection Sensitivity = 100%. Specificity = 88.9%. PPV = 98.8%. NPV = 100%. |
CE = Contrast Enhancement, FET = Fluoro-Ethyl-Tyrosine, NPV = Negative Predictive Value, PET = Positron Emission Topography, PPV = Positive Predictive Value.