Invasion ability of autocrine and paracrine effects in EOC-cell-line-derived exosomes. (A) Invasion ability was examined in epi-OCSPCs and MSC-OCSPCs treated with ES2, ES2TR, ES2 tumor spheres, and ES2TR tumor sphere exosomes and not treated with said substances. The invasion ability was only significantly enhanced in the MSC-OCSPCs (** p < 0.01) treated with ES2 exosomes, not in epi-OCSPCs. (B) The invasion ability was substantially increased in the MSC-OCSPCs that were treated with ES2 exosomes than in those that were not (* p < 0.05; *** p < 0.001). Simultaneously, the invasion ability was greater in ES2 cells treated with MSC-OCSPC exosomes than in those without MSC-OCSPC exosomes (** p < 0.01).