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Histograms of relative abundance values for wt-TTR, mTTR, and hTTR tetramers present in 21 °C solutions initially containing wt-TTR and (A) L55P, (B) V30M, (C) F87A, and (D) T119M homotetramers. The relative abundance values provide evidence that SUE occurs spontaneously in water and that stability of mutant tetramers dictates the SUE process.
