Table 1.
Average fold change in ABC transporter levels in exosomes and recipient cells.
| ABC Transporter | Cell Lines | Exosomes | ||||
|---|---|---|---|---|---|---|
| Control | GH | Doxo | Doxo + GH | Doxo + GH + Peg | ||
| ABCC1 | Malme-3M | 1.0 | 5.0 | 5.4 | 4.9 | 1.4 |
| SK-MEL-28 | 1.0 | 2.4 | 3.3 | 3.3 | 1.7 | |
| SK-MEL-30 | 1.0 | 7.2 | 6.0 | 6.1 | 1.4 | |
| ABCC2 | Malme-3M | 1.0 | 2.8 | 2.4 | 2.5 | 0.8 |
| SK-MEL-28 | 1.0 | 2.2 | 2.5 | 3.4 | 2.3 | |
| ABCB1 | SK-MEL-30 | 1.0 | 3.3 | 3.9 | 5.6 | 1.9 |
| Malme-3M | 1.0 | 3.2 | 3.9 | 3.5 | 1.2 | |
| ABCG2 | SK-MEL-28 | 1.0 | 1.4 | 1.5 | 1.6 | 1.0 |
| SK-MEL-30 | 1.0 | 2.7 | 3.2 | 2.9 | 1.9 | |
| Recipient cells | ||||||
| ExoControl | ExoGH | ExoDoxo | ExoDoxo+GH | ExoDoxo+GH+Peg | ||
| ABCC1 | Malme-3M | 1.0 | 2.0 | 2.0 | 1.6 | 0.5 |
| SK-MEL-28 | 1.0 | 1.0 | 1.6 | 1.4 | 0.8 | |
| ABCB1 | Malme-3M | 1.0 | 1.5 | 1.8 | 1.5 | 0.7 |
| SK-MEL-28 | 1.0 | 1.0 | 1.3 | 1.1 | 0.5 | |
| SK-MEL-30 | 1.0 | 1.5 | 2.1 | 1.5 | 0.9 | |
| ABCG2 | Malme-3M | 1.0 | 3.1 | 3.7 | 5.0 | 2.7 |
| SK-MEL-28 | 1.0 | 1.6 | 2.9 | 3.2 | 0.9 | |
| SK-MEL-30 | 1.0 | 1.7 | 1.3 | 1.5 | 1.8 | |
Average fold change is calculated based on the corresponding controls.