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. 2024 Jul 23;25(15):8018. doi: 10.3390/ijms25158018

Figure 4.

Figure 4

Neurotrophic factor receptor and muscarinic receptor levels of young and ageing EDL muscles. (A), Western blot analysis of neurotrophic receptors showing that TrkB-FL and its phosphorylated form, pTrkB-FL, do not change, but that there is a significant decrease in TrkB-T1 isoform and p75NTR receptor in ageing EDL. (B), Western blot analysis of PLCγ1 and p PLCγ1 shows no differences between young and ageing muscles. (C), Western blot analysis of muscarinic receptors, M1 and M2. (D), Western blot analysis of PLCβ and AC. Note that the protein level of M1 mAChR and PLCβ does not change with ageing but an important reduction in the M2 receptor occurs without affecting the membrane transducer adenylyl cyclase (AC). Data are represented as means ± SD. Statistical significance was determined using the Mann–Whitney test (* p value < 0.05; ** p value < 0.01). Statistical distribution significance is # p < 0.05.