Table 5.

Summarized table of Polynucleotides for Miscellaneous Applications.

Study	Application	Key Findings	Level
Park et al. [49]	Infra-orbital Dark Circles	PN is used to treat dark circles by improving skin elasticity and reducing fine lines and wrinkles.	IIIa
Yogya et al. [50]	Periorbital Wrinkles	Non-insulated microneedle radiofrequency (MRF) with PN showed greater improvements in wrinkle depth and skin elasticity compared to MRF alone.	IIa
Gulfan et al. [51]	Melasma	Non-insulated microneedle radiofrequency (MNRF) with PN showed better efficacy and faster improvement in melasma severity and skin elasticity compared to MNRF alone.	IIb