Table 3.
Initial CT lesion patterns and their associations with mortality according to univariable Cox regression analysis.
| Whole Lung | Subpleural Region c | Inner Region | ||||
|---|---|---|---|---|---|---|
| Lesion Patterns a | Hazard Ratio (95% CI) |
p-Value | Hazard Ratio (95% CI) |
p-Value | Hazard Ratio (95% CI) |
p-Value |
| Emphysema (%) | 1.05 (0.96–1.14) | 0.32 | 1.09 (0.93–1.29) | 0.30 | 1.08 (0.90–1.30) | 0.39 |
| Consolidation + Fibrosis (%) | 1.6 (1.40–1.83) | <0.001 | 2.22 (1.75–2.82) | <0.001 | 2.30 (1.65–3.22) | <0.001 |
| Ground-glass opacity (%) | 1.12 (1.06–1.18) | <0.001 | 1.17 (1.04–1.32) | 0.008 | 1.23 (1.12–1.34) | <0.001 |
| Reticulation (%) | 1.17 (1.07–1.27) | 0.001 | 1.22 (1.12–1.32) | <0.001 | 1.55 (1.26–1.90) | <0.001 |
| Honeycombing + Traction bronchiectasis (%) | 1.16 (1.09–1.23) | <0.001 | 1.24 (1.08–1.42) | 0.002 | 1.63 (1.28–2.08) | <0.001 |
| Normal (%) | 0.67 (0.35–1.27) | 0.218 | 0.89 (0.86–0.93) | <0.001 | 0.92 (0.90–0.95) | <0.001 |
| Fibrotic lesion (%) b | 1.10 (1.06–1.14) | <0.001 | 1.17 (1.10–1.23) | <0.001 | 1.26 (1.14–1.38) | <0.001 |
Data in parentheses are the 95% confidence intervals. a CT lung lesion volume normalized for predicted total lung capacity. b Sum of values of consolidation, fibrosis, reticulation, honeycombing, and traction bronchiectasis. c The 10 mm-width area of the lung surface. CI, confidence intervals.