CE: Cholesterol ester Cer: Ceramides CLD: Chronic liver disease DG: Diglycerides DiHETrEs: Dihydroxy-eicosatrienoic acids DNL: De novo lipogenesis FA: Fatty acid FC: Free cholesterol LCFA: Long-chain fatty acid LC-MS: Liquid chromatography–mass spectrometry LPC: Lysophosphatidylcholine LFAT: high-fat liver HCC: Hepatocellular carcinoma HH: Hereditary hemochromatosis HETEs: Hydroxyeicosatetraenoic acids IHTG: Intrahepatic triglyceride IR: Insulin Resistance MALDI-MSI: Matrix-assisted laser desorption/ionization–mass spectrometry imaging MetS: Metabolic syndrome MUFA: Monounsaturated fatty acid

NAFLD: Non-alcoholic fatty liver disease NEFA: Non-esterified fatty acid NMR: Nuclear magnetic resonance PC: Phosphatidylcholine PE: Phosphatidylethanolamine PhC: Phosphocholine PL: Phospholipid PE-pl: PE-based plasmalogens PNPLA3: Patatin-like phospholipase domain containing 3 PUFA: Polyunsaturated fatty acid. RBC: Red blood cell SG: Sleeve gastrectomy SFA: Saturated fatty acid SM: Sphingomyelin S1P: Sphingosine 1 phosphate TG: Triglyceride TM6SF2: Transmembrane 6 superfamily member 2 T2DM: Type 2 Diabetes mellitus UPLC MS-QTOF: Ultraperformance liquid chromatography–Time-of-flight mass spectrometry