Table 4.
Impact of the M. chamomilla dry extract and its amino acid preparations on the duration of thiopental-induced sleep, t ± Δt.
| Active Ingredient/Group (n = 6) | Dose (mg/kg) | Average Duration of Sleep (min). | Soporific Effect (%) in Comparison to the Group Given Thiopental | Soporific Effect (%) in Comparison to the Group Given the Chamomile Extract | |
|---|---|---|---|---|---|
| Control group (1) | 0 | - | |||
| Gch | 2 | 25 | 79.67 ± 7.18 | 75.99 | 100 |
| 3 | 50 | 115.33 ± 12.60 | 110.02 | 100 | |
| 4 | 100 | 76.67 ± 9.91 * | 73.13 | 100 | |
| Gch-Arg | 5 | 25 | 74.99 ± 6.51 *# | 71.54 | −5.87 |
| 6 | 50 | 40.02 ± 5.93 *# | 40.09 | −65.30 | |
| 7 | 100 | 50.85 ± 7.55 *# | 48.50 | −33.68 | |
| Gch-Phe | 8 | 25 | 43.32 ± 8.33 *# | 41.32 | −45.63 |
| 9 | 50 | 54.46 ± 11.12 *# | 51.95 | −52.78 | |
| 10 | 100 | 57.77 ± 8.17 *# | 55.10 | −24.65 | |
| Gch-β-Ala | 11 | 25 | 132.88 ± 7.91 *# | 126.76 | 66.79 |
| 12 | 50 | 137.14 ± 3.19 *# | 130.82 | 18.91 | |
| 13 | 100 | 196.61 ± 11.69 *# | 187.55 | 156.44 | |
| Gch-Gly | 14 | 25 | 73.22 ± 6.10 *# | 71.54 | −8.10 |
| 15 | 50 | 105.76 ± 15.15 | 100.89 | −8.30 | |
| 16 | 100 | 93.21 ± 12.46 | 88.91 | 21.57 | |
| Gch-Val | 17 | 25 | 53.86 ± 5.52 *# | 51.37 | −32.40 |
| 18 | 50 | 61.13 ± 5.99 *# | 51.95 | −47.00 | |
| 19 | 100 | 95.54 ± 4.62 | 91.13 | 24.61 | |
| Gch-Lys | 20 | 25 | 206.27 ± 8.52 *# | 196.76 | 158.91 |
| 21 | 50 | 201.65 ± 6.88 *# | 192.35 | 74.85 | |
| 22 | 100 | 193.90 ± 14.71 *# | 184.96 | 152.90 | |
| Valerian extract (23) | 2.15 | 96.83 ± 8.46 | 92.37 | ||
| Thiopental (24) | 40 | 104.83 ± 8.76 | 100 | ||
Notes: * Statistically significant (p < 0.05) to the group that consumed sodium thiopental; # Statistically significant (p < 0.05) to the group that consumed AN NATUREL valerian syrup.