Table 4.
Details of patients under metoprolol maintenance treatment and metoprolol concentrations in biological samples
| No. | Weight (kg) | Height (cm) | Daily dose (mg) | Timea | Other co-administrated drugs | Plasma (µg·L− 1) | Urine (µg·L− 1) | EBC (µg·L− 1) |
|---|---|---|---|---|---|---|---|---|
| 1 | 60 | 153 | 50 (1 Per Day) | 19.0 | Metformin 1000 | < 0.4 | 177.89 | < 0.6 |
| 2 | 82 | 158 | 50 (2 Per Day) | 6.0 |
Metformin 1000 - Gliclazide 80 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 40– (Acetylsalicylic acid) ASA 80 |
10.92 | 117.39 | < 0.6 |
| 3 | 78 | 160 | 50 (2 Per Day) | 8.0 |
Metformin 500 - Gliclazide 60 - Pioglitazone 45 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 40 - ASA 80 |
78.14 | 4287.27 | < 0.6 |
| 4 | 70 | 148 | 95 (1 Per Day) | 8.0 |
Metformin 500 - Pioglitazone 45 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 - Spironolactone 25 Atorvastatin 20 - ASA 80 |
43.13 | 4990.65 | 18.95 |
| 5 | 75 | 145 | 95 (1 Per Day) | 19.0 |
Insulin Glargine 20 - Metformin 1000 - Gliclazide 60 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 ASA 80 - Fluoxetine 20 - Lorazepam 1 - FeFol |
88.74 | 1305.43 | < 0.6 |
| 6 | 75 | 140 | 50 (2 Per Day) | 7.0 |
Metformin 500 - Gliclazide 30 - Empagliflozin 10 - Linagliptin 5 Atorvastatin 20 - Fluoxetine 20 |
157.79 | 1132.14 | 2.83 |
| 7 | 55 | 153 | 47.5 (1 Per Day) | 20.0 |
Metformin 500 Losartan 50 - Hydrochlorothiazide 12.5 Levothyroxine 50 - Atorvastatin 20 |
4.23 | 433.43 | 2.89 |
| 8 | 78 | 165 | 47.5 (1 Per Day) | 9.0 |
Metformin 500 - Sitagliptin 50 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 20 |
97.07 | 4817.81 | 2.89 |
| 9 | 75 | 150 | 47.5 (1 Per Day) | 8.5 |
Insulin Glargine - Insulin Aspart - Metformin 1000 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 20 |
< 0.4 | 3.57 | 9.01 |
| 10 | 70 | 170 | 50 (2 Per Day) | 9.0 |
Metformin 500 Levothyroxine 50 - Atorvastatin 20 - ASA 80 - Finasteride 5 - Tamsulosin 0.4 - Prostatan |
48.36 | 1779.78 | 6.97 |
| 11 | 70 | 145 | 50 (2 Per Day) | 6.5 |
Metformin 1000 - Sitagliptin 50 Atorvastatin 20 |
150.80 | 4999.58 | 2.09 |
| 12 | 70 | 165 | 47.5 (1 Per Day) | 19.0 | Metformin 1000 - Sitagliptin 50 | 8.80 | 1504.60 | 20.91 |
| 13 | 50 | 150 | 50 (2 Per Day) | 7.0 |
Metformin 500 - Gliclazide 30 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Atorvastatin 10 - ASA 80 |
86.80 | 1985.09 | 3.48 |
| 14 | 75 | 148 | 95 (1 Per Day) | 6.5 |
Metformin 500 - Sitagliptin 50 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Rosuvastatin 5 - ASA 80 |
111.88 | 1310.59 | 7.22 |
| 15 | 60 | 150 | 50 (2 Per Day) | 5.0 |
Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Levothyroxine 50 - Calcium |
< 0.4 | 111.02 | 11.06 |
| 16 | 95 | 155 | 50 (2 Per Day) | 7.0 |
Metformin 500 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Atorvastatin 10 |
91.04 | 2805.57 | 2.63 |
| 17 | 70 | 185 | 47.5 (1 Per Day) | 10.5 |
Insulin Glargine - Insulin Aspart Rosuvastatin 10 |
24.28 | 4864.05 | 3.42 |
| 18 | 97 | 155 | 1/2 of 50 (2 Per Day) | 19.0 |
Insulin Glargine - Insulin Aspart - Metformin 1000 - Empagliflozin 5 - Valsartan 160 - Amlodipine 5 Atorvastatin 20 |
1.15 | 18.77 | 2.42 |
| 19 | 110 | 162 | 95 (1 Per Day) | 8.5 |
Insulin Isophane Biphasic 70/30 - Metformin 500 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 - Furosemide 40 Atorvastatin 20 - Citalopram 20 |
96.81 | 3024.96 | < 0.6 |
| 20 | 103 | 164 | 95 (1 Per Day) | 7.5 |
Metformin 1000 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 20 - ASA 80 |
55.53 | 859.43 | 1.94 |
| 21 | 80 | 170 | 50 (2 Per Day) | 10.5 |
Metformin 1000 - Gliclazide 60 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 20 |
41.67 | 363.20 | 3.37 |
| 22 | 73 | 160 | 50 (2 Per Day) | 7.0 |
Insulin - Metformin 500 - Sitagliptin 50 Levothyroxine 0.1 - Rosuvastatin 20 - ASA 80 |
136.34 | < 0.7 | 4.38 |
| 23 | 62 | 148 | 1/2 of 50 (2 Per Day) | 8.0 |
Metformin 500 - Acarbose 50 Losartan 25 - Amlodipine 5 Rosuvastatin 40 - ASA 80 |
9.94 | 2999.49 | < 0.6 |
| 24 | 85 | 162 | 95 (1 Per Day) | 9.0 |
Insulin Glargine 30 - Metformin 1000 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 |
123.75 | No sample | 3.70 |
| 25 | 60 | 155 | 50 (2 Per Day) | 9.0 |
Metformin 500 - Sitagliptin 50 - Gliclazide 30 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Atorvastatin 10 - Exemestane |
187.38 | 9050.70 | 2.71 |
| 26 | 51 | 148 | 1/4 of 50 (2 Per Day) | 5.5 |
Metformin 500 - Linagliptin 5 Losartan 25 Levothyroxine 50 - Atorvastatin 20 - ASA 80 |
26.34 | < 0.7 | < 0.6 |
| 27 | 66 | 155 | 95 (2 Per Day) | 8.0 |
Metformin 500 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Atorvastatin 20 - Escitalopram 10 |
162.60 | 4033.88 | < 0.6 |
| 28 | 63 | 148 | 47.5 (1 Per Day) | 20.0 |
Metformin 500 - Empagliflozin 10 - Linagliptin 5 Levothyroxine 50 - ASA 80 - Carbamazepine 200 - Sertraline 50 - Clonazepam |
5.76 | 226.91 | 3.20 |
| 29 | 67 | 150 | 50 (1 Per Day) | 7.0 |
Insulin Aspart Losartan 50 - Hydrochlorothiazide 12.5 ASA 80 |
13.11 | 1146.99 | 2.66 |
| 30 | 108 | 189 | 47.5 (2 Per Day) | 7.5 |
Insulin - Metformin 1000 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 |
59.36 | 1935.67 | < 0.6 |
| 31 | 81 | 168 | 47.5 (1 Per Day) | 8.0 |
Metformin 500 - Gliclazide 30 Losartan 50 - Hydrochlorothiazide 12.5 Rosuvastatin 10 - ASA 80 - Clonazepam |
< 0.4 | 350.95 | < 0.6 |
| 32 | 80 | 150 | 50 (2 Per Day) | 6.0 |
Metformin 500 - Gliclazide 30 - Empagliflozin 10 - Linagliptin 5 Atorvastatin 20 - Phenazopyridine - Gabapentin 300 |
3.38 | No sample | 2.11 |
| 33 | 65 | 152 | 50 (1 Per Day) | 4.0 |
Metformin 1000 - Glibenclamide - Acarbose Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 20 - ASA 80 |
40.20 | 435.35 | 2.11 |
| 34 | 71 | 150 | 47.5 (1 Per Day) | 5.5 |
Metformin 500 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 10 - ASA 80 |
32.55 | 251.89 | < 0.6 |
| 35 | 92 | 175 | 50 (2 Per Day) | 9.0 |
Insulin - Empagliflozin 10 - Linagliptin 5 Valsartan - Amlodipine 5 Atorvastatin 20 - ASA 80 - Nephrovit |
54.46 | 744.17 | < 0.6 |
| 36 | 70 | 152 | 50 (2 Per Day) | 8.5 |
Metformin 500 - Sitagliptin 50 - Gliclazide 30 Losartan 50 - Hydrochlorothiazide 12.5 Atorvastatin 20 - ASA 80 |
51.55 | No sample | < 0.6 |
| 37 | 72 | 155 | 50 (2 Per Day) | 10.0 |
Metformin 1000 - Empagliflozin 10 - Linagliptin 5 - Pioglitazone 15 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Ropixon 20 - ASA 80 |
112.88 | No sample | < 0.6 |
| 38 | 83 | 175 | 47.5 (1 Per Day) | 9.0 |
Metformin 1000 - Empagliflozin 10 - Linagliptin 5 Losartan 50 - Hydrochlorothiazide 12.5 - Amlodipine 5 Atorvastatin 20 - ASA 80 |
6.53 | 110.80 | < 0.6 |
| 39 | 65 | 140 | 95 (1 Per Day) | 7.0 |
Metformin 500 - Sitagliptin 50 - Gliclazide 60 Valsartan - Hydrochlorothiazide 25 - Amlodipine 5 Atorvastatin 20 - ASA 80 - Clonidine 0.2 - Sertraline 50 |
253.21 | No sample | < 0.6 |
aTime difference of the sampling to the last administration of metoprolol (in hours)