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. 2024 Aug 9;30:117. doi: 10.1186/s10020-024-00887-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The expression of ox-LDL and LOX-1 in degenerative cartilage endplate tissues. A MRI was used to examine human intervertebral disc, with T2-weighted signal, and representative MRI images were displayed. Each group consisted of 5 samples, with the corresponding intervertebral disc indicated by red arrows. B General organization of human cartilage end plates. C H&E staining of human CEP tissues. Scale bar = 50 μm. D Immunohistochemical staining of ox-LDL, LOX-1 in CEP tissues. Scale bar = 50 μm. E, F Quantitative analysis of ox-LDL, LOX-1 expression in human CEP tissues. G Immunohistochemical staining of cell senescence and calcification markers P16, P21, MMP13, COL1, OCN in human CEP tissues. Scale bar = 50 μm. H Quantitative analysis of P16, P21, MMP13, COL1, OCN expression in human CEP tissues. Each image represented a sample from a total of 5 examined samples, Scale bar = 500 μm. Compared to LVF group, *p < 0.05, **p < 0.01, ns indicated non-significance difference