Figure 8.

Model of nephrocyte damage mediated by mitochondrial dynamics Schematic representation of the regulation of mitochondrial dynamics. Mitochondrial dynamics can be disrupted by the genetic modification of the Pink1–Park pathway (Pink1/park/Marf overexpression or silencing; red upward arrow indicates increase; blue downward arrow indicates decrease). The resulting changes in mitochondrial morphology lead to mitochondrial dysfunction, which impairs the endocytic trafficking pathway, resulting in protein aggregation, and increased reactive oxygen species (ROS), culminating in further tissue damage. Marf, Mitochondrial assembly regulatory factor; Park, Parkin; Pink1, PTEN-induced putative kinase 1.