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Splicing of circRNAs versus mRNAs. This figure demonstrates the non-canonical back splicing of the circRNAs from the pre-messenger RNA, showing its single-strand closed-loop structure, which is resistant to RNase, versus the canonical splicing of the mRNA with its polyadenylated 3′ tail. [CircRNA: circular RNA; mRNA: messenger RNA, Poly-A-tail: polyadenylated tail].
