Table 5.
CircRNAs in different liver diseases retrieved from circRNADisease v2.0 bioinformatics database search.
| Downregulated circRNAs | |||
| CircRNAs |
Hepatic Disease/ Biological Function |
Mechanism | Molecular Mechanism/Associated miR (Sponged miR) |
| circRNA_0046366 | Hepatocellular steatosis | - | circRNA_0046366/miR-34a/PPAR-a signaling |
| hsa_circ_0070963, hsa_circ_0061893 and hsa_circ_0013255 | Liver fibrosis | - | - |
| circRNAs_100395 | Liver cancer | inhibits cell proliferation, induces apoptosis | miR-1228 |
| circScd1 | NAFLD | encourages the JAK2/STAT5 pathway, which causes fatty liver disease | - |
| circCDK13 | Liver cancer | suppresses progression via JAK/STAT and PI3K/Akt signaling | - |
| circRNA_101764 | HBV-related HCC | - | hsa-miR-181 |
| circ_03848, circ_08236, circ_13398 and circ_15013 |
Liver regeneration | - | - |
| circRNA-4099 | Hepatitis | unknown/triggers keap1/Nrf2 and p38MAPK | miR-706 aggravating H2O2-induced injury |
| Upregulated circRNAs | |||
| CircRNAs |
Hepatic Disease/ Biological Function |
Mechanism |
Molecular Mechanism/ Associated miR (Sponged miR) |
| hsa_circRNA_0000657, hsa_circRNA_0000659, hsa_circRNA_0003247, hsa_circRNA_0001535 |
Hepatotoxicity | - | - |
| hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 | Liver fibrosis | - | - miR-9-5p - |
| circZFR, circFUT8 circIPO11 |
Liver cancer | - | - |
| circMEG3 | Liver cancer | inhibits telomerase activity, shortens telomere lifespan, reduces Cbf5 | - |
| circRNA-0067835 | Liver fibrosis | promotes cell proliferation, inhibits apoptosis | miR-155 to promote FOXO3a |
| circ_0091579 | Liver cancer | promotes proliferative and metastasis | miR-490-3p |
| hsa_circ_0003056 hsa_circ_0067127 |
Carcinoma | - | - |
| circRNA-1984 | HSCs-related to fibrosis | - | miR-146b |
| circ_0015756 | Hepatoblastoma | - | - |
| hsa_circ_0000594 | Hepatoblastoma | - | mir-217/SIRT1 regulatory axis |
| circFBLIM1 | Hepatoblastoma | Promotes cell viability, proliferation, invasion | miR-346-ceRNA to regulate FBLIM1 expression |
| circHMGCS1 | Hepatoblastoma | Regulates proliferation, apoptosis and glutaminolysis | miR-503-5p/IGF/PI3K/AKT axis; regulates IGF2 and IGF1R expression |
| circ-PWWP2A | Fibrogenesis | Downstream reactor of TGF-ß and LPS | miR-203 and miR-223 |
http://cgga.org.cn:9091/circRNADisease/ accessed on 17 May 2023. Table 5 demonstrates the upregulated and downregulated circRNAs in the different hepatic diseases while denoting the involved molecular mechanism and/or associated miRNA as retrieved from circRNADisease v2.0 bioinformatics database, http://cgga.org.cn:9091/circRNADisease/, accessed on 17 May 2023. [AKT: AKT serine/threonine kinase; FBLIM1: Filamin-binding LIM protein 1; FOXO3a: Forkhead box O3; IGF: insulin-like growth factor; IGF1R: insulin-like growth factor 1 receptor; JAK2: Janus kinase 2; Keap 1: Kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1; HSCs: hepatic stellate cells; LPS: Lipopolysaccharide; NAFLD: non-alcoholic fatty liver disease; Nrf2: nuclear factor erythroid 2 [NF-E2]-related factor 2; PI3K: phosphoinositide 3-kinase; PPAR: Peroxisome proliferator-activated receptor; p38MAPK: p38 mitogen-activated protein kinase; SIRT1: Sirtuin 1; STAT5: signal transducer and activator of transcription 5; TGF-ß: transforming growth factor beta].