Figure 1.

Sequence alignment of archaeal F and P subunits with eukaryotic RPB4 and RPB12 proteins, respectively. (A) Alignment of two representative archaeal F subunit sequences with two eukaryotic RPB4 subunits (mj, M.jannaschii; mt, M.thermoautotrophicum; sp, Schizosaccharomyces pombe; hs, Homo sapiens). Note the limited degree of overall homology and the rather disperse location of similar or identical present in all four polypeptide sequences shown. (B) Alignment of two representative archaeal P subunit sequences with two eukaryotic RPB12 subunits (species abbreviations as above). Dark shaded residues are identical and light shaded residues are similar.