Figure 5. ComBatLS and ComBat-GAM both effectively remove batch effects from consortium data containing over 50 studies.

A) Characteristics of curated LBCC sample by primary study and summarized across the full sample. B) Distributions of subjects’ mean centiles across all brain features within each primary study. Centiles are calculated from brain charts fit on data harmonized using ComBat-GAM or ComBatLS, or on unharmonized data, and averaged within subjects across features.