Table 2:
Odds ratios for prostate cancer by polygenic risk score (PRS) percentile stratified by genetic population
| European | African | |||||
|---|---|---|---|---|---|---|
| PRS Category | Case/Control | OR (95% CI) | P-Value | Case/Control | OR (95 %CI) | P-Value |
|
| ||||||
| 0–10% | 203/15450 | 0.28 (0.25–0.33) | 4.52E-68 | 9/295 | 0.55 (0.26–1.18) | 1.24E-01 |
| 10–20% | 336/15254 | 0.51 (0.45–0.57) | 1.95E-31 | 13/280 | 0.91 (0.49–1.69) | 7.58E-01 |
| 20–30% | 453/15138 | 0.6 (0.54–0.67) | 1.77E-20 | 19/281 | 1.35 (0.76–2.38) | 3.07E-01 |
| 30–40% | 501/15040 | 0.73 (0.66–0.8) | 4.25E-10 | 22/263 | 1.05 (0.58–1.9) | 8.78E-01 |
| 40–60% | 1471/29540 | Reference | Reference | 34/549 | Reference | Reference |
| 60–70% | 953/14506 | 1.29 (1.19–1.41) | 3.58E-09 | 26/263 | 1.28 (0.72–2.26) | 4.06E-01 |
| 70–80% | 1148/14286 | 1.59 (1.46–1.72) | 6.27E-29 | 24/273 | 1.36 (0.79–2.36) | 2.73E-01 |
| 80–90% | 1425/13899 | 2.11 (1.95–2.28) | 2.76E-80 | 25/264 | 1.76 (1.04–3) | 3.64E-02 |
| 90–100% | 2299/12804 | 3.62 (3.38–3.89) | 1.04E-276 | 38/248 | 1.9 (1.13–3.2) | 1.49E-02 |
Odds ratios (OR) and 95%confidence intervals for the association between a specified Polygenic Risk Score 269 (PRS269) decile and Prostate Cancer (PCa) compared to individuals in the 40-60% percentile of scores (reference) for European and African ancestry samples. The number of cases and controls for each population and percentile group is given. PRS269 values were standardized per population before analysis.