Table 3:

Odds ratios for prostate cancer in relation to polygenic risk score (PRS) by neighborhood deprivation quartiles.

nSES Variables	Deprivation Q1 PRS Odds Ratio (95% CI)	Deprivation Q2 PRS Odds Ratio (95% CI)	Deprivation Q3 PRS Odds Ratio (95% CI)	Deprivation Q4 PRS Odds Ratio (95% CI)	Heterogeneity p-value
Index of Multiple Deprivation	1.99 (1.89 – 2.1)	2.12 (2 – 2.24)	2.14 (2.02 – 2.26)	2.03 (1.91 – 2.15)	0.226
Income Index of Deprivation	2.03 (1.93 – 2.14)	2.03 (1.92 – 2.15)	2.15 (2.04 – 2.28)	2.06 (1.94 – 2.19)	0.418
Employment Index of Deprivation	2.04 (1.94 – 2.15)	2.05 (1.94 – 2.16)	2.17 (2.06 – 2.3)	2.01 (1.89 – 2.13)	0.231
Health Index of Deprivation	2.03 (1.92 – 2.14)	2.14 (2.03 – 2.26)	2.12 (2 – 2.24)	1.97 (1.86 – 2.1)	0.159
Education Index of Deprivation	2.1 (1.99 – 2.21)	2.03 (1.92 – 2.15)	2.06 (1.95 – 2.18)	2.08 (1.95 – 2.2)	0.857
Housing/Services Index of Deprivation	2.03 (1.92 – 2.15)	2.06 (1.94 – 2.17)	2.02 (1.91 – 2.14)	2.16 (2.04 – 2.29)	0.324
Crime Index of Deprivation	2.01 (1.91 – 2.13)	2.02 (1.91 – 2.13)	2.19 (2.07 – 2.32)	2.06 (1.94 – 2.18)	0.115
Environment Index of Deprivation	1.98 (1.88 – 2.09)	2.11 (2 – 2.23)	2.09 (1.98 – 2.22)	2.1 (1.98 – 2.22)	0.37
Townsend Index Index of Deprivation	2.13 (2.02 – 2.25)	1.93 (1.83 – 2.03)	2.1 (1.99 – 2.23)	2.12 (2 – 2.25)	0.029

Odds ratios (OR) and 95% confidence intervals for the association between continuous PRS₂₆₉ values and PCa stratified by individuals in each neighborhood socioeconomic status (nSES) deprivation quartile for men of European ancestry. PRS₂₆₉ values were standardized in the European ancestry sample prior to separating on deprivation quartile. Heterogeneity P-value calculated from a Cochran’s Q test comparing PRS₂₆₉ associations within each stratified nSES deprivation index.