Table 2.

ARC-HBR Criteria for assessing high bleeding risk at time of PCI.

Major Criteria

Minor Criteria

Anticipated use of long-term oral anticoagulation Severe or end-stage CKD (eGFR < 30 mL/min) Hemoglobin < 11 g/dL Spontaneous bleeding requiring hospitalization or transfusion in the past 6 months or at any time, if recurrent Moderate or severe baseline thrombocytopenia (platelet count < 100 × 109/L) Chronic bleeding diathesis Liver cirrhosis with portal hypertension Active malignancy within the last 12 months (excluding non-melanoma skin cancer) Previous spontaneous ICH (at any time), previous traumatic ICH within the past 12 months, presence of brain AVM, moderate or severe ischemic stroke within the past 6 months Non-deferrable major surgery on DAPT Recent major surgery or major trauma within 30 days before PCI

Age > 75 years of age Moderate CKD (eGFR 30–59 mL/min) Hemoglobin 11–12.9 g/dL for men and 11–11.9 g/dL for women Spontaneous bleeding requiring hospitalization or transfusion within the past 12 months not meeting the major criterion Long-term use of oral NSAIDs or steroids Any ischemic stroke at any time not meeting the major criterion

ARC-HBR: Academic Research Consortium for High Bleeding Risk; AVM: arteriovenous malformation; CKD: chronic kidney disease; DAPT: dual antiplatelet therapy; eGFR: estimated glomerular filtration rate; ICH: intracranial hemorrhage; NSAID: non-steroidal anti-inflammatory drug; PCI: percutaneous coronary intervention.