Table 3.
Multivariable regression analysis of the relationship between UHR groups and its components groups with circulating α-klotho
| Exposure | Tertile group | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|
| β(95% CI) | P | β(95% CI) | P | β(95% CI) | P | ||
| UHR | 0.68–8.73 | Ref | - | Ref | - | Ref | - |
| 8.73–12.85 | -46.4 (-59.4, -33.4) | < 0.001 | -44.1 (-57.1, -31.2) | < 0.001 | -35.1 (-49.4, -20.8) | < 0.001 | |
| 12.93–39.62 | -72.6 (-85.5, -59.7) | < 0.001 | -54.7 (-68.8, -40.6) | < 0.001 | -37.5 (-54.3, -20.7) | < 0.001 | |
| groups trend | -7.5 (-8.9, -6.2) | < 0.001 | -5.6 (-7.1, -4.1) | < 0.001 | -3.8 (-5.5, -2.0) | < 0.001 | |
| UA | 0.40–4.70 | Ref | Ref | Ref | - | ||
| 4.80–5.90 | -46.7 (-59.8, -33.6) | < 0.001 | -38.3 (-51.7, -24.9) | < 0.001 | -32.8 (-47.6, -17.9) | < 0.001 | |
| 6.10–13.00 | -98.9 (-111.8, -86.0) | < 0.001 | -86.5 (-100.5, -72.5) | < 0.001 | -68.7 (-85.0, -52.4) | < 0.001 | |
| groups trend | -36.7 (-41.4, -31.9) | < 0.001 | -32.1 (-37.3, -27.0) | < 0.001 | -25.5 (-31.5, -19.4) | < 0.001 | |
| HDL | 10.82–42.92 | Ref | Ref | Ref | - | ||
| 44.08–56.84 | 10.5 (-2.5, 23.6) | 0.113 | 0.8 (-12.3, 13.9) | 0.905 | 0.2 (-14.2, 14.6) | 0.98 | |
| 58.00-225.83 | 25.7 (12.4, 39.0) | < 0.001 | 7.4 (-6.5, 21.3) | 0.296 | 2.5 (-13.6, 18.6) | 0.759 | |
| groups trend | 0.8 (0.4, 1.3) | < 0.001 | 0.3 (-0.2, 0.7) | 0.265 | 0.1 (-0.4, 0.6) | 0.742 | |
Note Model 1:unadjusted; Model 2: adjust for gender, age, race; Model 3: adjust for gender, age, race, marital status, Income-poverty ratio, BMI, education, smoking, drinking, eGFR, VD, CVD, DM, HTN, Cancer, CKD, Stroke