Figure 3.

CRKL inhibition reduces cell viability. (A,B) The measurement of cell viability after different time points of CRKL and CRK inhibition in SNU182 and Hep3B cells showed reduced cell viability for CRKL inhibition. In contrast, CRK inhibition did not consistently affect cell viability. (C,D) CRKL but not CRK knockdown decreased cell survival in a colony formation assay. Exemplary images are shown. (A–D) Nonsense siRNA (nons.) transfected cells served as negative controls. (A–D) Statistical tests: Dunnett’s multiple comparison with nons. as reference. ns = not significant. p ≤ 0.05 *, p ≤ 0.01 **, p ≤ 0.001 ***.