Skip to main content
. 2024 Aug 5;25(15):8549. doi: 10.3390/ijms25158549

Figure 6.

Figure 6

CRKL expression correlates with YAP activation in HCC patients. (A) The immunohistochemical staining of a tissue-microarray against CRKL, YAP and KI67 illustrated higher CRKL and YAP protein expression in HCC tissues compared to non-tumor liver tissue. The staining intensity increased with tumor grading and KI67 positivity. Three HCC samples with an increasing tumor grade, as well as a non-tumor liver sample, are shown as examples. Spearman’s rank correlation revealed significant correlations between CRKL protein expression, YAP abundance, KI67 staining and tumor grading. (B) Spearman’s rank correlation showed a significant correlation between CRKL mRNA expression and the YAP mRNA levels in HCC patients (N = 242) [29]. (C) CRKL mRNA expression correlated with a YAP target gene signature (CIN25 [4]) in HCC patients (N = 242). For Spearman’s rank correlation, a score of the target signature was calculated by summing up the normalized expression values of the 25 CIN genes. p ≤ 0.001 ***.