Figure 1.

Expression of APP and BACE in the larval CNS mimics kis loss of function mutant phenotypes. High-resolution confocal micrographs showing the glutamate receptor subunit, GluRIIC (A, green), endocytosis as indicated by FM 1-43FX (B, green), and the GTPase Rab11 (C, green) at the 6/7 NMJ in the listed genotypes. Fluorescence intensities, relative to controls, are depicted in right histograms. HRP (magenta) denotes the presynaptic motor neuron. Scale bars = 5 µm. * = p < 0.05, *** = p < 0.001.