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Representative working model. OGE synergistically increases cisplatin-induced DNA damage by activating proteasomal degradation of BRCA1. Abbreviations/symbols: OGE, aqueous extract of O. gratissimum; Pt, cisplatin; BRCA1, breast cancer type 1 susceptibility protein; HCC, hepatocellular carcinoma; Resistant, cisplatin-resistant HCC cells; Sensitive, cisplatin sensitive HCC cells.
