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. 2024 Aug 5;25(15):8541. doi: 10.3390/ijms25158541

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Next-generation RNA sequencing was used to analyze the effect of dapagliflozin on rescuing hypoxic cardiomyocyte H9c2. RNA-sequencing volcano plots of hypoxia-cultured H9c2 at (A) low (2.4 µg/mL) and (B) high (5 µg/mL) concentrations of dapagliflozin treatment. (C) Heatmap analysis of the trends in gene changes related to SIRTs and (D) verification qPCR analysis. (E) Heatmap of DEGs involved in apoptosis-associated signaling, and (F) qPCR verification in hypoxic H9c2 cells incubated with dapagliflozin. * p < 0.05 compared with normal control; # p < 0.05 compared with hypoxia control.