Table 1.
List of candidate genes that may be involved in AMI-caused cardiac myocardial pathology and remodeling.
| Categories | Diseases or Functions Annotation | Molecules Counts | Molecules | p-Value |
|---|---|---|---|---|
| Cardiac Enlargement | Enlargement of heart | 61 | ACTG2,ADA,ADIPOQ,ALDH1A2,APOE,BGN,BNIP3,CACNA1H,CACNB3,Ccl2,COX7A1,CPT2,CTSC,CYBB,EGFR,EGLN3,ELN,FASN,FGFR1,GATA5,GJA5,GPX1,GPX3,GPX7,GUCY1A1,HCK,HMOX1,HOPX,IGF1,IL17RA,IL33,ITGAV,ITGB3,LIF,MDK,MMP2,MYOZ2,NCF1,NPPA,P2RY6,PDGFC,PITX2,PLA2G4A,PLIN5,POSTN,PRKCD,PTGS2,S100A10,S100A6,SDC1,SERPINE1,SLC1A3,SLCO2A1,STAB1,TCF15,THBS2,THBS4,TIMP1,TNFRSF11B,TNFRSF1B,TRIM54 | 1.99 × 10−8 |
| Hypertrophy of heart | 42 | ACTG2,ADA,ADIPOQ,APOE,CACNA1H,Ccl2,CPT2,CTSC,CYBB,EGFR,ELN,FASN,GATA5,GPX3,GUCY1A1,HCK,HMOX1,HOPX,IGF1,IL33,ITGB3,LIF,MDK,MYOZ2,NCF1,NPPA,P2RY6,PDGFC,PLA2G4A,PLIN5,POSTN,PRKCD,PTGS2,S100A10,S100A6,SERPINE1,TCF15,THBS4,TIMP1,TNFRSF11B,TNFRSF1B,TRIM54 | 8.04 × 10−6 | |
| Cardiac Dysfunction | Left ventricular dysfunction | 25 | ADIPOQ,APOE,BGN,BNIP3,Ccl2,CCR2,CYBB,GATA5,GPX1,HMOX1,IL10,ITGB3,MDK,MGP,MMP2,NCF1,NPPA,PLIN5,POSTN,PTX3,SERPINE1,SLCO2A1,SPP1,TIMP1,TLR2 | 5.4 × 10−6 |
| Dysfunction of heart | 26 | ADIPOQ,APOE,BGN,BNIP3,Ccl2,CCR2,CYBB,GATA5,GPX1,HMOX1,IL10,ITGB3,MDK,MGP,MMP2,NCF1,NPPA,PLIN5,POSTN,PTX3,SCD,SERPINE1,SLCO2A1,SPP1,TIMP1,TLR2 | 1.48 × 10−4 | |
| Cardiac Fibrosis | Fibrosis of heart | 26 | APOE,BGN,BUB1B,CACNA1H,CDON,CYBB,EGR1,GPX1,HMOX1,HOPX,IL10,KRT18,NCF1,NPPA,PADI4,PDGFC,POSTN,PTGS2,PTX3,SERPINE1,SGCA,SPP1,THBS2,TIMP1,TLR2,TNFRSF1B | 5.2 × 10−4 |
| Interstitial fibrosis of left ventricle | 4 | CYBB,GPX1,NPPA,PTX3 | 1.46 × 10−3 | |
| Interstitial fibrosis of heart | 7 | BUB1B,CYBB,GPX1,NCF1,NPPA,POSTN,PTX3 | 4.89 × 10−3 | |
| Cardiac Necrosis/Cell Death | Cell death of heart | 22 | ADIPOQ,BNIP3,CASP3,CCN4,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,PADI4,SCD,SFRP2,SGCA,SPRR1A,STAR,THBS2,THBS4,TRIM54 | 8.84 × 10−5 |
| Cell death of heart cells | 18 | ADIPOQ,BNIP3,CASP3,CCN4,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,SFRP2,SPRR1A,STAR,THBS2,TRIM54 | 1.2 × 10−3 | |
| Apoptosis of heart | 16 | ADIPOQ,BNIP3,CASP3,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,SCD,SFRP2,STAR,TRIM54 | 2.44 × 10−3 | |
| Necrosis of cardiac muscle | 17 | ADIPOQ,BNIP3,CASP3,CCN4,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,SGCA,SPRR1A,THBS2,TRIM54 | 3.45 × 10−3 | |
| Apoptosis of heart cells | 15 | ADIPOQ,BNIP3,CASP3,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,SFRP2,STAR,TRIM54 | 4.2 × 10−3 | |
| Cell death of cardiomyocytes | 16 | ADIPOQ,BNIP3,CASP3,CCN4,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,SPRR1A,THBS2,TRIM54 | 5.05 × 10−3 | |
| Apoptosis of cardiomyocytes | 13 | ADIPOQ,BNIP3,CASP3,CYBB,E2F1,FASN,FSTL1,HMOX1,IGF1,IL10,IL1RN,IL33,TRIM54 | 0.0168 | |
| Cardiac Damage | Rupture of heart | 5 | BGN,GDF15,POSTN,SERPINE1,TRIM54 | 5.22 × 10−5 |
| Damage of heart | 10 | ADIPOQ,BGN,GDF15,HMOX1,IL10,INHBA,POSTN,SERPINE1,THBS4,TRIM54 | 2.76 × 10−3 | |
| Rupture of heart ventricle | 2 | BGN,POSTN | 3.02 × 10−3 | |
| Rupture of myocardium | 2 | GDF15,SERPINE1 | 8.74 × 10−3 | |
| Damage of myocardium | 3 | ADIPOQ,GDF15,SERPINE1 | 0.0149 | |
| Rupture of left ventricle | 1 | BGN | 0.055 | |
| Reperfusion injury of myocardium | 1 | ADIPOQ | 0.055 | |
| Cardiotoxicity | 1 | CYBB | 0.156 | |
| Injury of heart | 2 | ADIPOQ,INHBA | 0.442 | |
| Cardiac Infarction | Myocardial infarction | 22 | ACTA2,ADIPOQ,APOE,Ccl2,Ccl7,CD44,COL3A1,CSF1R,CSF3R,CXCR4,CYBB,FCER1G,FSTL1,GDF15,HMOX1,IL10,KRT18,KRT8,NCF2,OLR1,PADI4,TNFRSF1B | 2.89 × 10−9 |
| Early stage myocardial infarction | 2 | Ccl2,Ccl7 | 8.74 × 10−3 |