Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Aug 1;25(15):8421. doi: 10.3390/ijms25158421

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation showing virus–host cell interactions and Gal3 inhibition blocking viral entry to host cells. Gal3 is believed to play critical role in viral entry to host cells. Interaction between the galectin-like S1-NTD (N-terminal domain of the virus S1 spike protein) and host sialic acids could be critical for viral entry as means of stabilizing the interaction between S1-CTD (C-terminal domain of the virus S1 spike protein) and ACE2. Moreover, host Gal3 may participate in additional interactions with virus spike glycoprotein for further stabilization, contributing to prolonged infection and severity of disease. Therefore, Gal3 inhibition may disrupt attachment of SARS-CoV-2 to cell surface, preventing entry to host cells (adapted from Refs. [72,80]). The SARS-CoV-2 image was taken from the Centers for Disease Control and Prevention (CDC) website (https://stacks.cdc.gov/view/cdc/86942, access on 20 May 2024).