Figure 1.

Schematic representation and sequence alignment of MeCP2 with Rett syndrome mutations identified. (A) MeCP2 with its two functional domains MBD and TRD indicated. Rett syndrome associated mutations found to date are marked, with missense mutations located on the top, and nonsense and deletion/insertion mutations on the bottom. Mutations used in this study are in bold type. The NLS is marked. (B) Sequence alignment of MeCP2 from human (h), mouse (m) and Xenopus (x). Conserved residues are shaded and mutations used in this study are marked by open triangles for missense mutations and closed triangles for nonsense mutations.