Fig. 5. Accurate MenG classification of publicly available datasets sheds light on previous studies based on WHO grading.

(A) Heatmap (top) and t-SNE (bottom) of the top 1000 most DEGs from a cohort of meningiomas studied by Viaene et al. (30). The WHO grade I tumors that did not progress were all MenG B and separate clearly from the other tumors. (B) PCA of RNA-seq and DNA methylation data of 86 spatially distinct samples from 13 meningiomas studied by Magill et al. (33), segregated by WHO grade, as in the original study (top) and by MenG (bottom). MenG demonstrates markedly better cluster separation.