Table 4.
Predicted toxicity properties and probability of penetration of the blood–brain barrier for the studies imides.
| Compound | ||||||
|---|---|---|---|---|---|---|
| I | II | III | IV | V | VI | |
| Carcinogenicity | inactive | inactive | inactive | inactive | inactive | inactive |
| Immunotoxicity | inactive | inactive | inactive | inactive | inactive | inactive |
| Mutagenicity | inactive | inactive | inactive | inactive | inactive | inactive |
| Cytotoxicity | inactive | inactive | inactive | inactive | inactive | inactive |
| LD50 (mg/kg) | 4000 | 728 | 4000 | 4000 | 4000 | 315 |
| class | 5 | 4 | 5 | 5 | 5 | 4 |
| BBB (probability) | 0.98 | 0.98 | 0.98 | 0.99 | 0.92 | 0.98 |