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. 2024 Aug 9;10(32):eadl5473. doi: 10.1126/sciadv.adl5473

Fig. 5. Immune cells from foci are recruited by IPF-specific bronchial vessels.

Fig. 5.

(A and B) Spatial plots show, for one IPF tissue section, (A) the abundance of immune niche–associated cell types and (B) the immune niche distribution and zoom into H&E-stained tissue for highlighted regions. (C) Xenium mRNA in situ hybridization data on an adjacent tissue section from (A). (D) Multiplexed protein immunofluorescence on an adjacent tissue section from (A). (E) Bubble plot summarizing the number of interactions between cell types within the rebuilt immune niche in the scRNA-seq PF-ILD atlas data. (F) Number of interactions within the immune niche per communication category. (G) Heatmap of statistically significant ligand-receptor pairs from the cell-cell contact category within the immune niche.