Table 2.
GRADE summary of evidence.
| Quality Assessment | No. of Patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of Studies | Design | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Honey Dressing | Control | Relative (95% CI) |
Absolute | ||
| Mean time to achieve wound healing (Better indicated by lower values) | ||||||||||||
| 6 | randomized trials | serious 1 | serious 2 | no serious indirectness | no serious imprecision | reporting bias 3 | 384 | 440 | - | MD 17.13 lower (from 26.37 to 7.89 and less) | ⊕OOO VERY LOW |
CRITICAL |
| Complete wound healing rate | ||||||||||||
| 3 | randomized trials | serious 1 | serious 2 | no serious indirectness | serious 4 | reporting bias 3 | 127/229 (55.5%) |
96/221 (43.4%) |
RR 2 (0.78 to 5.1) | 434 more per 1000 (from 96 and less to 1000 and more) | ⊕OOO VERY LOW |
CRITICAL |
| 30% | 300 more per 1000 (from 66 and less to 1000 and more) | |||||||||||
| Percentage of wound healing (%) (Better indicated by lower values) | ||||||||||||
| 3 | randomized trials | serious 1 | serious 2 | no serious indirectness | no serious imprecision | reporting bias 3 | 265 | 289 | - | MD 18.31 higher (from 8.86 to 27.76 and higher) | ⊕OOO VERY LOW |
CRITICAL |
| Bacterial clearance time of wounds (Better indicated by lower values) | ||||||||||||
| 2 | randomized trials | serious 1 | serious 2 | no serious indirectness | no serious imprecision | reporting bias 3 | 69 | 101 | - | MD 11.36 lower (from 25.91 and lower to 3.18 and higher) | ⊕OOO VERY LOW |
IMPORTANT |
1 Downgrading one level for some concerns or high risk of attrition bias in included studies. 2 Downgrading one level for the heterogeneity ≥ 50%. 3 Downgrading one level for potential publication bias. 4 Downgrading one level for the 95% confidence interval ranges from 0.78 to 5.10.