Fig. 1.

Analysis of the risk factors for the development of early acute GI toxicity. (a) Values of the mean rectal dose across the patient population, stratified by RT intent (n = 215) and by toxicity group. (b) Density plots of the risk score associated with RT-related pro-inflammatory cytokines (polycytokinic risk) across the overall population (grey) and in the toxicity groups (blue, red). (c) Frequency of potential protective and risk factors measured within the toxicity groups. (d) Statistic of the intestinal microbiota bacterial genera detected in the RT-baseline faecal samples of the patient population with a relative abundance of at least 2%; bacterial genera measured with at least 2% relative abundance in at least 10% of the sample population define the core intestinal microbiota. (e) Shannon's index, (f) Simpson's index and (g) number of core genera measured from the microbiota profiles (genus level) and stratified by toxicity group (a small vertical jitter is applied to dots to improve visualisation).